When I first saw the show, during the first season, I found myself oddly sympathizing with the group of geeks, the four male protagonists who are smarter than the rest of us put together but just don't GET the normal things of life. Sure, it is exaggerated to make a point, but the subtle undercurrents struck a chord with me. Always managing to say the wrong them? Been there. Not understanding sarcasm? All too familiar. Being unsure about that whole dating thing works? Boy howdy, yes. The scene that struck the strongest chord in me is probably the one where they all show up to a party they are invited to at precisely the time they were told, and no one is there yet, nor is the hostess (Penny, their eminently normal neighbor) even dressed. They are baffled because, well, isn't this the time you told us the party started? It's a very funny moment that shows clearly that this group of men simply do not get social mores, but I have to say on this one I completely was on their side. Seriously, if you aren't supposed to show up on time to a party, how late are you supposed to be? If you want people to show up later, why not just start the party later? I have never, NEVER understood the fashionably late thing. It remains one of my minor pet peeves.
Then you have Sheldon. Socially inept to the point that he insults most people he meets, absolutely incapable of recognizing sarcasm or subtle hints, very rigid in his schedule and absolutely catatonic at the thought of breaking out of it.
Sheldon is an Aspie. And he manages to make you love you because of it. Sheldon is way smarter than I am, and I hope I have a few more social skills in my arsenal, but there isn't much difference between us. Well, I might be cuter too.
To watch a perfect example of this, I suggest you watch this short clip (embedding is disabled, sorry!).
Watch the Big Bang Theory if you don't already. You won't be disappointed.